The influence of customer integration, integrated information technology, and relationship commitment on performance: a mediating and moderating analysis in supply chain management context

Esta investigación amplía el creciente cuerpo de la literatura sobre la integración de la cadena de suministro. A partir de diferentes teorías, desarrollamos hipótesis que proponen relaciones positivas entre la tecnología de información integrada, la integración de clientes, el compromiso relacional y el rendimiento financiero. Además, investigamos los roles complementarios del tamaño del departamento de TI y el apoyo de la alta dirección. Los resultados a partir de una muestra de 205 empresas de Egipto indican que la tecnología de información integrada y la integración de clientes pueden mejorar el rendimiento financiero. Adicionalmente, los resultados muestran un efecto mediador positivo de la integración de clientes en la relación entre tecnología de información integrada y el rendimiento financiero. Además, se confirma que el tamaño del departamento de TI y el apoyo de la alta dirección están relacionados significativamente con la tecnología de información integrada. Finalmente, nuestros resultados también muestran un efecto positivo directo del compromiso relacional en la integración de clientes, así como un efecto moderador positivo del compromiso relacional en la relación entre la tecnología de información integrada y la integración de clientes.This research extends the developing body of literature on supply chain integration. Theorizing from the supply chain integration literatures, we develop hypotheses proposing direct, mediating, and moderating relations between integrated information technology, customer integration, relationship commitment, and financial performance. Also, we investigate the complementary roles of IT department size and top management support. Our findings from a sample of 205 firms in Egypt indicate that integrated information technology and customer integration can improve financial performance. In addition, our results show a mediating and positive effect of customer integration on the relation between integrated information technology and financial performance. Also, information technology department size and top management support are significantly related to integrated information technology. Finally, our results also show a direct and positive effect of relationship commitment on the customer integration, and a moderating and positive effect of relationship commitment on the relationship between integrated information technology and customer integration

Integrated information technology and firm performance: mediating and moderating effects in supply chain management context

This thesis extends the developing body of literature on supply chain integration (SCI). We develop hypotheses proposing positive relationships between integrated IT, supplier integration, customer integration, internal integration, and financial performance. Also, we investigate the complementary roles of IT department size and top management support. CFA and SEM analysis of a survey of 205 firms in Egypt indicates that integrated IT, supplier integration, customer integration, and internal integration can improve financial performance. In addition, integrated IT has a direct positive effect on SCI dimensions. Also, it is confirmed that IT department size and top management support are significantly related to integrated IT. Finally, we found direct and moderating effects of trust, relationship commitment, and hierarchical organizational culture on SCI dimensions, and on the relationship between integrated IT and SCI dimensions. This finding suggests that firms should focus on the important roles of IT technology to improve financial performance through SCI

The direct and indirect effects of internal enablers on internal integration and business performance

The present paper aims to assess both the direct as well as the indirect effects of internal enablers on internal integration and business performance in the supply chain. A full managerial comprehension of the connection between supply chain integration (SCI) and business performance is missing so far and earlier results are inconclusive. To fill this gap, this study expands the growing body of research on SCI and contributes to the SCM field by explaining the direct and indirect effects of internal enablers on internal integration and business performance. Results show that hierarchical organizational culture influences internal integration and supply chain performance, that top management support and information technology department size influence internal integration, and, finally, that supply chain performance impacts operational performance. These findings confirm the relevance for firms to pay attention to those key internal enablers of internal integration, and their benefits on business performance. Considering our results, future research should deepen on the influence of internal integration on business performance by focusing on the links between internal integration and the other dimensions of SCI, that is supplier and customer integration, as well as with the external side of the supply chain performance

Cubic liquid crystalline nanoparticles containing a polysaccharide from Ulva fasciata with potent antihyperlipidaemic activity

The present study involves the preparation of cubic liquid crystalline nanoparticles (cubsomes) for liver targeting to assess the potential of a formulated bioactive polysaccharide isolated from the hot aqueous extract of Ulva fasciata as an alternative natural agent with anti-hyperlipidaemic activity. Cubosomal nanoparticles were prepared by disrupting the cubic gel phase of the polysaccharide and water in the presence of a surfactant. Different lipid matrices and stabilizers were tested. All the formulations were in the nanosize range and showed sufficient negative charge to inhibit the aggregation of the cubosomes. Drug entrapment efficiencies (EEs%) were determined and in vitro release studies were performed. Transmission electron microscopy (TEM) and differential scanning calorimetry were used to analyze the loaded cubosomal nanoparticles containing glyceryl monostearate (GMO 2.25 g), poloxamer 407 (0.25 g) and 50 mg of the polysaccharide. A preclinical study comparing the cubic liquid crystalline nanoparticles containing polysaccharide to fluvastatin as a reference drug in hyperlipidaemic rats was conducted. The rats treated with the polysaccharide- loaded cubosomes showed significant decreases in total cholesterol (TC), triglycerides (TG) and total lipid (TL) compared to the untreated HL rats. In addition, oxidative stress and antioxidant biomarkers were measured in the HL rats. Compared to the untreated HL rats, the cubosome treated rats showed a significant reduction in malondialdehyde (MDA), whereas insignificant changes were detected in nitric oxide (NO), glutathione (GSH) levels and total antioxidant capacity (TAC). Further, vascular and intercellular adhesion molecules (VCAM, ICAM), and myeloperoxidase were demonstrated. A histopathological examination was conducted to study the alterations in histopathological lesions and to document the biochemical results. In conclusion, this study demonstrates the superiority of using a natural lipid regulator such as polysaccharide loaded cubosomes instead of fluvastatin